01Why trials matter today

Dr. Catherine Osei-Bonsu
Endocrinologist
University of California, San Francisco
“
Bisphosphonates have been the workhorse for two decades — but half of patients stop within a year. The monoclonal antibody trials we're running now are showing vertebral fracture reductions of 75% over 24 months. That's not incremental. That's a different conversation entirely.
18
Years in research
12
Trials led
Metabolic Bone Disease
IIICompleted — FDA Approved
Romosozumab (Phase III)
Sclerostin inhibitor — increases bone formation + decreases resorption
75% lower incidence of vertebral fractures at 24 months vs. placebo
Vertebral fracture reduction75%
Clinical fracture reduction36%
BMD increase (spine)13%
4,093 participants in study
Trial eligibility overview
Most common inclusion and exclusion criteria across 147 active trials
T-score ≤ −2.5 (DEXA confirmed)
RequiredPostmenopausal women, any age
Primary cohortMen 60+ with vertebral compression
Actively recruitingPrior bisphosphonate use (>12 mo)
Eligible — key subgroupHip fracture within 24 months
Priority enrollmentActive cancer or recent chemo
Exclusion criterionSevere renal impairment (eGFR <30)
Exclusion criterion147
Active trials
68
Avg. participant age
74%
Female participants
02Who qualifies — and who's being missed

Dr. Marcus Thibodeau
Rheumatologist
Mayo Clinic, Rochester
“
Bone density screening still reaches fewer than 25% of eligible patients. Men are diagnosed years later than women — if at all. Our trials specifically include patients over 65 with vertebral compression, because that's where the treatment gap is most dangerous.
14
Years in research
8
Trials led
Osteoporosis & Fracture Prevention
03What participants actually experience

Dr. Priya Ramanathan
Clinical Researcher
Johns Hopkins School of Medicine
“
The concern I hear most often is side effects. When we compare denosumab biosimilar trials to standard bisphosphonate therapy, the discontinuation rates drop by more than half. Patients stay because the experience is different — subcutaneous injection every six months instead of daily pills.
11
Years in research
6
Trials led
Bone Metabolism & Gene Therapy
Side-effect comparison
Discontinuation rates across treatment categories
Discontinuation rate (%) within 12 months
Source: Comparative analysis across published Phase II/III trial data, 2022–2025. Discontinuation rate = patients who stopped treatment within 12 months.
LiveFree · HIPAA-compliant · No referral needed
Marrow Matching Engine
Four-variable intake → ranked trial list by eligibility probability
8 minutes average to first matched trial · 94% eligibility accuracy
Eligibility accuracy94%
Avg. trials matched per patient5
Avg. distance to nearest trial12 mi
12,400 participants in study
04How matching works

Dr. James Okonkwo
Principal Investigator
Cleveland Clinic Foundation
“
Marrow's matching algorithm starts with four data points: your diagnosis date, current medication, T-score range, and ZIP code. From those, we can surface the three to seven trials with the highest likelihood of eligibility — before a single phone call. The average patient finds a match within 8 minutes.
20
Years in research
23
Trials led
Translational Bone Research
Research PartnersTrials backed by institutions
Trials backed by institutions
you already trust.
Every trial in the Marrow network is sponsored or co-sponsored by a research hospital with active IRB oversight and independent safety monitoring boards.
JH
Johns Hopkins MedicineMA
Mayo ClinicCC
Cleveland ClinicUC
UCSF HealthMG
Massachusetts General HospitalSM
Stanford MedicineNY
NYU Langone HealthNW
Northwestern MedicineVU
Vanderbilt University Medical CenterDU
Duke University HospitalUM
University of Michigan HealthCS
Cedars-Sinai Medical CenterJH
Johns Hopkins MedicineMA
Mayo ClinicCC
Cleveland ClinicUC
UCSF HealthMG
Massachusetts General HospitalSM
Stanford MedicineNY
NYU Langone HealthNW
Northwestern MedicineVU
Vanderbilt University Medical CenterDU
Duke University HospitalUM
University of Michigan HealthCS
Cedars-Sinai Medical CenterHIPAA Compliant
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IRB-Approved Trials
Every trial in our network has active Institutional Review Board oversight and independent safety monitoring.
No Cost. Ever.
Clinical trial participation is free by law. We never charge patients, and we never will.
Local Matches First
Results ranked by proximity to your ZIP code. Average matched trial is 12 miles away.
210
Research centers
47
States with active trials
94%
Eligibility match accuracy
< 8
Minutes to first match