Clinical Trial Network · Active 2026

Your next
treatment is already
in trial.

Before a therapy reaches the pharmacy shelf, it goes through years of clinical testing. Marrow connects bone density patients to those trials — free, fast, and matched to your diagnosis.

0+
Active trials nationwide
Bisphosphonates, monoclonal antibodies, gene therapies
0+
Participants enrolled
Across 47 states and 210 research centers
0
Miles to nearest trial
Average distance for matched patients in 2025

No cost to participate. Ever.

L3–L5
Normal (T > −1.0)
Low bone mass (−2.5 to −1.0)
Osteoporosis (T ≤ −2.5)
T-score ≤ −2.5

WHO threshold for osteoporosis diagnosis — the starting point for trial eligibility

Hear from specialists
01
Why trials matter today
Portrait of Dr. Catherine Osei-Bonsu, Endocrinologist at University of California, San Francisco
Dr. Catherine Osei-Bonsu
Endocrinologist
University of California, San Francisco
“
Bisphosphonates have been the workhorse for two decades — but half of patients stop within a year. The monoclonal antibody trials we're running now are showing vertebral fracture reductions of 75% over 24 months. That's not incremental. That's a different conversation entirely.
18
Years in research
12
Trials led
Metabolic Bone Disease
IIICompleted — FDA Approved

Romosozumab (Phase III)

Sclerostin inhibitor — increases bone formation + decreases resorption

75% lower incidence of vertebral fractures at 24 months vs. placebo

Vertebral fracture reduction75%
Clinical fracture reduction36%
BMD increase (spine)13%
4,093 participants in study

Trial eligibility overview

Most common inclusion and exclusion criteria across 147 active trials

T-score ≤ −2.5 (DEXA confirmed)
Required
Postmenopausal women, any age
Primary cohort
Men 60+ with vertebral compression
Actively recruiting
Prior bisphosphonate use (>12 mo)
Eligible — key subgroup
Hip fracture within 24 months
Priority enrollment
Active cancer or recent chemo
Exclusion criterion
Severe renal impairment (eGFR <30)
Exclusion criterion
147
Active trials
68
Avg. participant age
74%
Female participants
02
Who qualifies — and who's being missed
Portrait of Dr. Marcus Thibodeau, Rheumatologist at Mayo Clinic, Rochester
Dr. Marcus Thibodeau
Rheumatologist
Mayo Clinic, Rochester
“
Bone density screening still reaches fewer than 25% of eligible patients. Men are diagnosed years later than women — if at all. Our trials specifically include patients over 65 with vertebral compression, because that's where the treatment gap is most dangerous.
14
Years in research
8
Trials led
Osteoporosis & Fracture Prevention
03
What participants actually experience
Portrait of Dr. Priya Ramanathan, Clinical Researcher at Johns Hopkins School of Medicine
Dr. Priya Ramanathan
Clinical Researcher
Johns Hopkins School of Medicine
“
The concern I hear most often is side effects. When we compare denosumab biosimilar trials to standard bisphosphonate therapy, the discontinuation rates drop by more than half. Patients stay because the experience is different — subcutaneous injection every six months instead of daily pills.
11
Years in research
6
Trials led
Bone Metabolism & Gene Therapy

Side-effect comparison

Discontinuation rates across treatment categories

Discontinuation rate (%) within 12 months
Oral bisphosphonates50%
Denosumab (monoclonal Ab)21%
Romosozumab (trial)14%
14% stop treatment
Gene therapy (emerging)9%
9% stop treatment

Source: Comparative analysis across published Phase II/III trial data, 2022–2025. Discontinuation rate = patients who stopped treatment within 12 months.

LiveFree · HIPAA-compliant · No referral needed

Marrow Matching Engine

Four-variable intake → ranked trial list by eligibility probability

8 minutes average to first matched trial · 94% eligibility accuracy

Eligibility accuracy94%
Avg. trials matched per patient5
Avg. distance to nearest trial12 mi
12,400 participants in study
04
How matching works
Portrait of Dr. James Okonkwo, Principal Investigator at Cleveland Clinic Foundation
Dr. James Okonkwo
Principal Investigator
Cleveland Clinic Foundation
“
Marrow's matching algorithm starts with four data points: your diagnosis date, current medication, T-score range, and ZIP code. From those, we can surface the three to seven trials with the highest likelihood of eligibility — before a single phone call. The average patient finds a match within 8 minutes.
20
Years in research
23
Trials led
Translational Bone Research
Three specialists have just made the case

The treatment that fits your scan
may already be in trial.

Tell us your T-score range, current medication, diagnosis date, and ZIP code. In under 8 minutes, you'll see every trial you qualify for — ranked by distance.

No cost to participate. Ever.

Find Trials Near You
HIPAA-compliant · No referral needed
01
Diagnosis date
02
Current medication
03
T-score range
04
ZIP code
Research Partners

Trials backed by institutions
you already trust.

Every trial in the Marrow network is sponsored or co-sponsored by a research hospital with active IRB oversight and independent safety monitoring boards.

JH
Johns Hopkins Medicine
MA
Mayo Clinic
CC
Cleveland Clinic
UC
UCSF Health
MG
Massachusetts General Hospital
SM
Stanford Medicine
NY
NYU Langone Health
NW
Northwestern Medicine
VU
Vanderbilt University Medical Center
DU
Duke University Hospital
UM
University of Michigan Health
CS
Cedars-Sinai Medical Center
JH
Johns Hopkins Medicine
MA
Mayo Clinic
CC
Cleveland Clinic
UC
UCSF Health
MG
Massachusetts General Hospital
SM
Stanford Medicine
NY
NYU Langone Health
NW
Northwestern Medicine
VU
Vanderbilt University Medical Center
DU
Duke University Hospital
UM
University of Michigan Health
CS
Cedars-Sinai Medical Center
HIPAA Compliant
All intake data encrypted in transit and at rest. We never share your information without explicit consent.
IRB-Approved Trials
Every trial in our network has active Institutional Review Board oversight and independent safety monitoring.
No Cost. Ever.
Clinical trial participation is free by law. We never charge patients, and we never will.
Local Matches First
Results ranked by proximity to your ZIP code. Average matched trial is 12 miles away.
210
Research centers
47
States with active trials
94%
Eligibility match accuracy
< 8
Minutes to first match
Five specialists. One conclusion.

Fear pivots into
possibility
the moment you know
what's available.

Bisphosphonates. Monoclonal antibodies. Gene therapies. The next generation of osteoporosis treatment is already in clinical testing — and your T-score may qualify you today.

No cost to participate. Ever.

HIPAA-compliant intake
Under 8 minutes
Matched by location
IRB-approved trials only
Marrow is not a healthcare provider. We do not offer medical advice. All trial information sourced from ClinicalTrials.gov and participating institutions.

No cost to participate. Ever.

Find Trials Near You